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By Kim at Havdis AI News Team, approved by Andreas Lyhammer
Elite Traveler
Is PDRN the New Gold Standard For Skin Repair?
By Bridget March · Published October 11, 2026
Image: Elite Traveler
This article explores the growing popularity of PDRN (polydeoxyribonucleotide), purified DNA fragments originally used in wound-healing medicine and now featured in Korean-influenced injectable "skin boosters" and topical skincare. Aesthetic physician Dr Christine Hall and surgeon Dr Ash Soni discuss how PDRN activates the adenosine A2A receptor to support tissue repair and reduce inflammation, while noting regulatory differences: CE marking is required for injectable use in Europe, while the ingredient lacks FDA approval in the US. The piece highlights challenges with topical absorption due to molecule size, citing Medik8's Exo-PDRN Prismatic+, which uses a tetrahedral structure and plant-derived PDRN to aid penetration. Able C&C CEO Yoojung Shin predicts future growth will focus on bioactive longevity ingredients and advanced delivery technologies, including microspicule systems said to significantly increase absorption.
“It is a relatively large molecule, so meaningful penetration through intact skin is challenging”
Our view
This piece reflects growing mainstream interest in PDRN as a serious, long-term skincare ingredient rather than a passing trend. It underscores how delivery technology and thoughtful formulation, not just headline ingredient concentration, determine real-world results — a useful perspective for brands and formulators building considered, evidence-aware products in this space.
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