Paper from 1985
Chemical Tool Reveals How DNA Repair Enzymes Find and Cut Damaged Sites
A 1985 biochemistry study using methoxyamine to map how uracil-DNA glycosylase and AP endonuclease act on a uracil-containing DNA substrate.
Read more →From the literature
Science
What the published research says about PDRN. Havdis's AI Science Team works through the published research on PubMed and explains the papers that matter in plain language — with the source linked, every time.
Paper from 1985
Early Study Measures DNA Flexibility to Improve Gene-Cloning Methods
1985 study uses T4 ligase and electron microscopy to measure DNA flexibility, informing models for optimizing recombinant DNA cloning reactions.
Read more →Paper from 1985
Cystamine Shows Mixed Results Against Radiation Damage in Rat Blood Cells
A look back at a 1985 Radiobiologiia study on chromatin breakdown in rat white blood cells under radiation, and whether cystamine affected outcomes.
Read more →Paper from 1984
Bacterial Enzyme Found to Repair Radiation-Damaged DNA Building Block
1984 Nucleic Acids Research study: an E. coli enzyme excises gamma radiation-damaged adenine residues from synthetic polydeoxyribonucleotide chains.
Read more →Paper from 1984
Enzyme Study Reveals How DNA Strand Structure Drives Two Cellular ATPases
A 1984 Cell Structure and Function study on how DNA strand structure activates two FM3A cell ATPases, B and C3.
Read more →Paper from 1984
Bacterial Enzyme Found to Strip Damaged Thymine Bases from DNA
1984 study on E. coli endonuclease III, a DNA glycosylase that excises oxidatively damaged thymine bases from polydeoxyribonucleotide chains.
Read more →Paper from 1984
Mice Show Distinct Antibody Patterns to Synthetic Double-Stranded RNA Complex
1984 study on how ten inbred mouse strains produced distinct antibody responses to the synthetic double-stranded RNA complex poly(G) . poly(C).
Read more →Paper from 1984
Raman Spectroscopy Reveals Shape-Shifting DNA Structures in Solution
1984 Raman spectroscopy study on how synthetic DNA duplexes shift between B, Z and A structural forms in solution.
Read more →Paper from 1983
Enzyme That Repairs Oxidized DNA Found in Mammalian Cells
1983 Biochemistry study: urea-DNA glycosylase, first known from E. coli, found repairing oxidized DNA in calf thymus and human fibroblast cells.
Read more →Paper from 1982
Bacterial Antibiotic-Degrading Enzyme Found Bound to a DNA Fragment
A 1982 biochemistry study on a bacterial beta-lactamase bound to a DNA fragment, early groundwork in polydeoxyribonucleotide chemistry.
Read more →Paper from 1982
Spaceflight Altered DNA and RNA Levels in Rat Immune Organs
A 1982 Cosmos-1129 biosatellite study on how spaceflight temporarily altered polydeoxyribonucleotide, DNA and RNA levels in rat spleen, thymus and other…
Read more →Paper from 1981
Spaceflight Stress Linked to DNA Breakdown in Rat Spleen and Thymus
1981 Cosmos biosatellite study on deoxyribonucleoprotein breakdown in rat spleen, thymus and liver after spaceflight stress.
Read more →Paper from 1980
Germinating Wheat Embryos Yield a New Single-Stranded DNA Fraction
1980 study on wheat embryo germination finds a cytoplasmic single-stranded polydeoxyribonucleotide fraction and its proposed link to nuclear DNA replication.
Read more →Paper from 1980
Bacterial Enzyme Found to Strip Radiation-Damaged Fragments from DNA
1980 Nucleic Acids Research study: E. coli enzyme excises radiation-damaged base fragments from synthetic polydeoxyribonucleotide DNA.
Read more →Paper from 1980
Enzyme From Wheat Germ Extends DNA Chains Without a Template
A 1980 Biochemical Journal study on a wheat germ enzyme that extends DNA chains without a template, compared to a mammalian thymus counterpart.
Read more →Paper from 1980
Folded DNA Fragments Explain Why Lupus Antibodies Bind Denatured DNA
A 1980 Journal of Clinical Investigation study on how folded regions in denatured DNA explain antibody binding in lupus patient serum.
Read more →Paper from 1979
Early NMR Study Finds Two Distinct Phosphate Environments in DNA Backbone
A 1979 J. Biol. Chem. NMR study finds two distinct phosphate environments in the backbone of synthetic poly(dA-dT) DNA.
Read more →Paper from 1979
Enzyme Pair Chooses Targets Based on Protein's Physical Surroundings
A 1979 Journal of Biochemistry study on how protein kinase A and G differ in targeting histone bound to polydeoxyribonucleotide.
Read more →Paper from 1979
Polydeoxyribonucleotide Found to Boost Histone Phosphorylation by a Protein Kinase
A 1979 study on polydeoxyribonucleotide stimulating histone phosphorylation by a cyclic-GMP-dependent protein kinase — a historical enzymology record.
Read more →Paper from 1978
Silkworm Gland Enzyme Identified as Alpha-Type DNA Polymerase
A look at a 1978 Biochimie study characterizing an alpha-like DNA polymerase purified from Bombyx mori silkworm glands.
Read more →Paper from 1977
Early Method Packages Recombinant DNA Directly Into Phage Particles
A 1977 PNAS methods paper on packaging recombinant DNA into bacteriophage particles in vitro using ligase enzymes, revisited for its place in nucleic-acid…
Read more →Paper from 1977
Synthetic DNA Primers Direct Reverse Transcription of Phage RNA
A 1977 Nucleic Acids Research study on how synthetic DNA primers direct reverse transcriptase to copy MS2 phage RNA into DNA.
Read more →Paper from 1977
Cell Enzyme Can Join RNA to DNA Using a DNA Template
A 1977 Biochemistry study on how mouse L-cell DNA ligase joins RNA to DNA on a polydeoxyribonucleotide template, examined for its enzymology.
Read more →Paper from 1976
Researchers Clone Bacterial Genes by Splicing DNA with Ligase Enzyme
A 1976 PNAS study on how Collins and colleagues built chimeric plasmids from ColE1 and E. coli DNA using EcoRI and T4 ligase.
Read more →Paper from 1976
Mutant Mouse Cells Point to a Possible Protein Joining DNA Segments
A look back at a 1976 Cell study on a temperature-sensitive mouse cell mutant that failed to join newly made DNA fragments into full chromosomes.
Read more →Paper from 1976
Bacterial Membrane Complexes Show DNA-Protein Filaments Tied to Replication Control
A look back at a 1976 Folia microbiologica study on DNA-protein filaments bound to Bacillus subtilis cell membranes and their link to replication.
Read more →Paper from 1975
Bacteriophage Gene Study Reveals How a Protein Coordinates DNA Repair Enzymes
How a 1975 PNAS study on bacteriophage T4 revealed gene 32 protein's role in coordinating DNA ligase during recombination and repair.
Read more →Paper from 1975
Three Distinct DNA-Copying Enzymes Isolated and Compared in Rat Liver
A look at a 1975 biochemistry study isolating three rat liver DNA polymerases and their distinct behavior on polydeoxyribonucleotide templates.
Read more →Paper from 1974
NMR Reveals How Ultraviolet Light Damages a DNA Fragment's Bases
A 1974 NMR study on how UV light damages thymine and cytosine bases in apurinic acid, an early polydeoxyribonucleotide model.
Read more →Paper from 1975
Bacteriophage Enzyme Purified From Infected Bacteria Shown to Copy Only Its Own DNA
A 1975 Journal of Biological Chemistry study purified a bacteriophage-induced RNA polymerase from Pseudomonas putida and mapped its DNA specificity.
Read more →Paper from 1974
Vaccinia Virus Enzyme Shown to Chemically Bond RNA Building Blocks to DNA Primers
A 1974 Journal of Virology study on a vaccinia virus enzyme that covalently bonds RNA chains to DNA and RNA primer molecules.
Read more →Paper from 1974
Histone Proteins Found to Control DNA-Copying Enzyme in Leukemia Virus
A 1974 Journal of Virology study on how histone proteins modulate a leukemia virus enzyme's RNA-to-DNA copying activity in vitro.
Read more →Paper from 1973
Some Synthetic DNA Pairs Show pH-Dependent "Memory" Effect
A 1973 Molecular Biology Reports study on synthetic DNA pairs reveals a pH-dependent, heat-reversible "trapped" structural state.
Read more →Paper from 1971
Classic Study Maps How Retroviral Enzymes Read RNA Versus DNA Templates
A 1971 PNAS study by Baltimore and Smoler on how retroviral DNA polymerase reads RNA versus DNA templates and requires a primer.
Read more →Paper from 1967
Manganese Outperforms Magnesium in Mouse Embryo DNA-Building Enzyme
A 1967 Biochemical Journal study on how a mouse embryo enzyme builds DNA chains, and why manganese outperformed magnesium as its cofactor.
Read more →Paper from 1965
Small DNA Fragments Trigger Antibody Response in Rabbits, 1965 Study Finds
A look back at a 1965 Science study on DNA fragments acting as haptens in rabbits, part of PDRN's long scientific paper trail.
Read more →Paper from 1967
A 1967 Biochemistry Paper on Building DNA Chains with Pyrophosphate Links
A look at a 1967 biochemistry paper on synthesizing a polydeoxyribonucleotide with an internal pyrophosphate linkage, and its place in PDRN's history.
Read more →Paper from 1966
Enzyme Purified From Mouse Tumour Cells Reveals Mechanics of DNA Synthesis
A look back at a 1966 Biochemical Journal study on DNA nucleotidyltransferase from mouse tumour cells, an early use of the term polydeoxyribonucleotide.
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